Protective Roles of Quercetin, Vitamin C and Pyridoxine on Lead Neurotoxicity via Enhanced Haematopoietic and Antioxidants Components

Abstract

The harmful effects of lead exposure, especially its effect on the nervous system, raise serious concerns worldwide. This study is aimed at evaluating the effect of Quercetin, Vitamin C and Pyridoxine on Haematology, biochemical and histology of the cerebral cortex on lead induced neurotoxicity using adult Wistar rat models. Materials and Methods: Forty male Wistar albino rats were divided into five groups: control, lead only, lead + Quercetin, lead + Pyridoxine, lead and Vitamin C. 100mg/kg/bw of lead was used to induce-toxicity for 7 days and treated with the following: Quercetin, Pyridoxine and Vitamin C were administrated orally respectively for 14 days. Hematological and biochemical samples were collected in three phases. The cerebral cortex was examined under light microscopy after H&E staining. Results: lead decreased all hematological parameters (PCV, WBC, RBC, HB and Platelets) examined and in the biochemical parameters, decreased slightly SOD, increased MDA and reduced significantly (p values) GSH. Quercetin, Vitamin C and Pyridoxine had strong curative effects on both hematological and biochemical parameters. On the histology, lead revealed mild glial cell infiltration. All treatment groups showed normal neuronal cells. Conclusion: Quercetin, Vitamin C and Pyridoxine showed neuroprotective effects against lead-induced neurotoxicity; therefore, they can be used as routine supplements against lead toxicity in endemic communities.